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Rachel Marsh¹, Xuejun Hao, Dongrong Xu

¹The MRI Unit, Division of Child & Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States. MarshR@childpsych.columbia.edu

Neuropsychologia

|June 24, 2010

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This study reveals how the brain processes spatial navigation and reward. The hippocampus is involved in reward receipt, while temporo-parietal regions are key for spatial learning and navigation.

Area of Science:

Neuroscience
Cognitive Science

Background:

Temporo-parietal cortices are known to mediate spatial navigation.
Neural mechanisms underlying reward-based spatial learning require further investigation.

Purpose of the Study:

To investigate the neural correlates of reward-based spatial learning.
To differentiate the roles of the hippocampus and temporo-parietal regions in spatial searching and reward processing.

Main Methods:

Twenty-five healthy adults completed a virtual reality functional magnetic resonance imaging (fMRI) task.
Participants learned to navigate an 8-arm radial maze using extra-maze cues to find rewards.

Main Results:

Spatial learning activated temporo-parietal regions, excluding the hippocampus.

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Reward receipt activated the hippocampus when navigation cues were randomized, preventing learning.

Conclusions:

This research distinguishes the roles of the hippocampus and temporo-parietal areas in spatial learning and reward processing.
The findings support translational research for comparing learning systems across species.