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Updated: Jun 12, 2026
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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres
Dylan G Gee1, Bharat B Biswal, Clare Kelly
1Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience at the NYU Langone Medical Center, New York, NY 10016, USA.
Neuroimage
|June 24, 2010
Summary
This study reveals that while positive brain connections are stronger within hemispheres, negative connections are stronger between hemispheres. This highlights how brain hemispheres integrate and segregate information processing.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Imaging
Background:
- Resting-state functional magnetic resonance imaging (fMRI) reveals functional connectivity between homologous brain regions.
- Heterotopic resting-state functional connectivity (RSFC) between non-homologous regions is less understood.
- Understanding hemispheric interaction is key to brain function.
Purpose of the Study:
- To characterize heterotopic RSFC by comparing it with intrahemispheric RSFC.
- To investigate the impact of hemispheric separation on brain processing integration and segregation.
- To explore regional variations in connectivity patterns.
Main Methods:
- Acquired resting-state fMRI data from 59 healthy participants.
- Analyzed inter-regional correlations of spontaneous low-frequency BOLD signal fluctuations.
- Utilized a probabilistic atlas to correlate time series from 112 cerebral regions.
Main Results:
- Positive RSFC was stronger within hemispheres, suggesting intrahemispheric integration.
- Negative RSFC was stronger between hemispheres, suggesting interhemispheric segregation.
- These patterns were prominent in frontal and heteromodal regions.
Conclusions:
- Hemispheric separation influences the integration and segregation of neural processing.
- Distinct patterns of positive and negative connectivity support different modes of interhemispheric interaction.
- Findings offer insights into brain function and potential applications in clinical populations.
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