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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Interplay between cholesterol and drug metabolism.
Tadeja Rezen1, Damjana Rozman, Jean-Marc Pascussi
1Center for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Zaloska 4, SI-1000 Ljubljana, Slovenia.
Biochimica Et Biophysica Acta
|June 24, 2010
Summary
Cholesterol and drug metabolism pathways are interconnected through nuclear receptors. These receptors coordinate the metabolism of cholesterol derivatives and the detoxification of foreign compounds, maintaining metabolic homeostasis.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Cholesterol metabolism involves complex pathways producing vital molecules like hormones and vitamin D.
- Maintaining cholesterol homeostasis is crucial, influenced by both internal and external factors, including medications.
- Drug metabolism is regulated by enzymes like cytochrome P450 and transporters, subject to feedback mechanisms.
Purpose of the Study:
- To review the functional interactions between cholesterol homeostasis and drug metabolism.
- To highlight the role of nuclear and steroid receptors in coordinating these pathways.
- To explain how these receptors act as metabolic sensors for maintaining homeostasis and detoxification.
Main Methods:
- Literature review of scientific publications.
- Analysis of regulatory mechanisms involving nuclear receptors (PXR, CAR, VDR, GR).
- Examination of the cross-talk between cholesterol metabolism and xenobiotic/endobiotic pathways.
Main Results:
- Cholesterol and related compounds influence drug-metabolizing enzyme induction.
- Nuclear receptors (PXR, CAR, VDR, GR) mediate cross-talk between cholesterol and drug metabolism.
- These receptors coordinate the metabolism of cholesterogenic compounds and xenobiotics.
Conclusions:
- A functional link exists between cholesterol homeostasis and drug metabolism, mediated by key nuclear receptors.
- These receptors ensure coordinated regulation for metabolic balance and defense against toxic compounds.
- Understanding these interactions is vital for comprehending drug efficacy and toxicity.
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