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Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

Potential for targeting the fibroblast growth factor receptors in breast cancer

Nancy E Hynes1, Julien H Dey

  • 1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. hynes@fmi.ch

Cancer Research
|June 24, 2010
PubMed

Insights

This review explores fibroblast growth factor receptors (FGFR) in breast cancer, highlighting their role in tumor development and discussing targeted therapies. Strategies for selecting patients for FGFR inhibitor treatment are also examined.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cause of death in women, with a significant portion of diagnoses lacking targeted therapies.
  • Fibroblast growth factor receptors (FGFR) have emerged as potential targets in various cancers, including breast cancer.

Purpose of the Study:

  • To review recent findings on the role of FGFR in breast cancer.
  • To discuss the development of therapeutics targeting FGFR.
  • To outline strategies for patient selection for FGFR-targeted therapies.

Main Methods:

  • Literature review of recent research on FGFR in breast cancer.
  • Analysis of data supporting FGFR's role in breast cancer pathogenesis.
  • Examination of ongoing therapeutic development for FGFR inhibitors.

Main Results:

  • FGFR signaling pathways are implicated in breast cancer growth and progression.
  • Several therapeutic approaches targeting FGFR are under investigation.
  • Patient stratification is crucial for effective FGFR inhibitor treatment.

Conclusions:

  • Targeting FGFR represents a promising strategy for a subset of breast cancer patients.
  • Further research is needed to optimize FGFR-targeted therapies and patient selection criteria.

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