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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Cause and Effect01:53

Cause and Effect

While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares often...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Rapid changes in night eating: considering mechanisms.

A Stunkard1, X-Y Lu

  • 1University of Pennsylvania, Philadelphia, Pennsylvania, USA. stunkard@mail.med.upenn.edu

Eating and Weight Disorders : EWD
|June 24, 2010
PubMed
Summary

Night Eating Syndrome (NES) involves disrupted meal timing and neuroendocrine factors in genetically susceptible individuals under stress. Evidence suggests the serotonergic system plays a key role, with SSRIs proving effective in treatment.

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Last Updated: Jun 12, 2026

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Sleep Medicine

Background:

  • Night Eating Syndrome (NES) is characterized by delayed circadian rhythms in eating and neuroendocrine functions.
  • NES affects genetically vulnerable individuals, often triggered by stress.
  • The underlying mechanisms of NES remain incompletely understood.

Purpose of the Study:

  • To investigate potential mechanisms underlying Night Eating Syndrome.
  • To explore the role of neuroendocrine system disruptions in NES.
  • To identify effective treatment strategies for NES.

Main Methods:

  • Case study analysis of two patients with rapid-onset NES.
  • Examination of long-term treatment outcomes.
  • Discussion of potential neuroendocrine system disruptions including the glucocorticoid, melanocortin, and serotonergic systems.

Main Results:

  • The study explored disruptions in the glucocorticoid, melanocortin, and serotonergic systems as potential mechanisms for NES.
  • Strong evidence supports the involvement of the serotonergic system in NES.
  • Selective serotonin reuptake inhibitors (SSRIs) demonstrated significant effectiveness in treating NES.

Conclusions:

  • The serotonergic system is implicated as a primary mechanism in Night Eating Syndrome.
  • SSRIs represent a highly effective therapeutic option for managing NES.
  • Further research into neuroendocrine regulation in NES is warranted.