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Updated: Jun 12, 2026
11:42
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Published on: November 4, 2019
Reprogramming adult hematopoietic cells
Shin Kaneko1, Makoto Otsu, Hiromitsu Nakauchi
1Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Current Opinion in Hematology
|June 24, 2010
Summary
Induced pluripotent stem cells (iPSCs) can be generated from hematopoietic cells, offering new avenues for regenerative medicine and disease research. This technology minimizes patient risk and burden while enabling therapeutic applications.
Area of Science:
- Molecular Biology
- Stem Cell Research
- Regenerative Medicine
Background:
- Recent molecular biology advances enable somatic cell reprogramming into pluripotent stem cells.
- Hematopoietic cells, like fibroblasts, can be reprogrammed to a pluripotent state.
Purpose of the Study:
- Review the relevance of hematopoietic cell reprogramming for basic research and regenerative medicine.
- Highlight how researchers can leverage these reprogramming technologies.
Main Methods:
- Retroviral-mediated introduction of defined factors (e.g., Yamanaka factors).
- Reprogramming of murine and human somatic cells, including hematopoietic cells.
Main Results:
- Somatic cells, including hematopoietic cells, can be reprogrammed to an embryonic stem cell-like state.
- Induced pluripotent stem cells (iPSCs) have been generated from various hematopoietic cell types in mice and humans.
Conclusions:
- Reprogramming adult hematopoietic cells offers a low-risk source of valuable materials for research and therapy.
- Patient-derived iPSCs can advance disease mechanism studies, drug screening, and cell-based therapies.
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