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Updated: Jun 12, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

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Published on: August 2, 2012

A ligand-chirality controlled supramolecular hydrogel.

Jiang-Shan Shen1, Guo-Juan Mao, Yu-Hua Zhou

  • 1Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China. jsshen@iue.ac.cn

Dalton Transactions (Cambridge, England : 2003)
|June 24, 2010
PubMed
Summary

Chiral phenylalanine ligands coordinated with copper ions form supramolecular hydrogels. Ligand chirality controls gelation, enabling visual sensing of chiral molecules.

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Area of Science:

  • Supramolecular chemistry
  • Coordination chemistry
  • Chiral materials science

Background:

  • Chirality plays a crucial role in molecular recognition and self-assembly.
  • Developing responsive and selective chiral materials is an ongoing challenge.
  • Supramolecular hydrogels offer versatile platforms for sensing applications.

Purpose of the Study:

  • To investigate the influence of ligand chirality on supramolecular hydrogel formation.
  • To explore the potential of phenylalanine-copper(II) metallogels for chiral sensing.
  • To establish a visual detection method for chiral molecules.

Main Methods:

  • In situ supramolecular hydrogel formation via coordination of phenylalanine (Phe) to Cu(II).
  • Systematic variation of enantiomeric excess (ee%) of Phe ligands.
  • Characterization of gelation properties and interactions (hydrogen bonding, hydrophobic, pi-pi stacking).

Main Results:

  • Successful formation of supramolecular hydrogels through Phe-Cu(II) coordination.
  • Gelation ability was directly correlated with the enantiomeric excess of Phe.
  • Decreased enantiomeric excess led to weakened or absent gelation, indicating stereoselectivity.
  • Hydrogen bonding, hydrophobic, and pi-pi stacking interactions were essential for gel stability.

Conclusions:

  • Ligand chirality is a critical factor in controlling Phe-Cu(II) supramolecular hydrogel formation.
  • The developed metallogelator exhibits stereoselectivity, enabling chiral recognition.
  • This work presents a promising platform for visual chiral sensing based on a tunable sol-to-gel transition.