Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of carbon-ion radiotherapy for prostate cancer after rectal surgery: a single-institution retrospective study.

Journal of radiation research·2026
Same author

Antibacterial Effects of Nanobubble Water and Its Potential Application in Healthcare-associated Infection Control.

In vivo (Athens, Greece)·2026
Same author

Serum from patients with acetylcholine receptor antibody-positive myasthenia gravis triggers pathogenic changes in human myotube cells.

Journal of neuroimmunology·2026
Same author

Carbon-Ion radiotherapy alone for inoperable locally advanced Non-Small cell lung cancer: A Japanese National registry study (J-CROS-LUNG).

Japanese journal of radiology·2026
Same author

[Expression of Concern] Establishment and evaluation of a new highly metastatic tumor cell line 5a‑D‑Luc‑ZsGreen expressing both luciferase and green fluorescent protein.

International journal of oncology·2025
Same author

Carbon-Ion Radiotherapy for Prostate Cancer in Patients with a History of Surgery for Benign Prostatic Hyperplasia.

Cancers·2025

Related Experiment Video

Updated: Jun 12, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Uptake decrease of proliferative PET tracer 18FLT in bone marrow after carbon ion therapy in lung cancer.

Mitsuru Koizumi1,2, Tsuneo Saga3, Masayuki Inubushi3

  • 1Diagnostic Imaging, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. mitsuru@nirs.go.jp.

Molecular Imaging and Biology
|June 24, 2010
PubMed
Summary

Carbon ion radiotherapy (CIRT) significantly reduces 3'-[¹⁸F]fluoro-3'-deoxy-L-thymidine (¹⁸FLT) uptake in bone marrow (BM). This decrease indicates diminished BM function, even at low radiation doses, highlighting the impact of CIRT on hematopoietic cells.

More Related Videos

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiotherapy

Background:

  • Carbon ion radiotherapy (CIRT) is an advanced cancer treatment.
  • Bone marrow (BM) function is crucial for hematopoietic cell production.
  • Assessing radiation effects on BM is important for treatment planning and patient outcomes.

Purpose of the Study:

  • To evaluate changes in 3 -[ ¹⁸F]fluoro-3 -deoxy-L-thymidine (¹⁸FLT) uptake in normal bone marrow (BM) following carbon ion radiotherapy (CIRT).
  • To determine the relationship between radiation dose and ¹⁸FLT uptake in irradiated BM.
  • To assess the temporal changes in BM function post-CIRT using ¹⁸FLT-PET/CT.

Main Methods:

  • Twenty-one non-small cell lung cancer patients undergoing CIRT were included.
  • ¹⁸FLT-positron emission tomography/computed tomography (PET/CT) scans were performed before and after CIRT.
  • Irradiated BM was categorized into dose groups: <10%, 10-30%, and >30% of the maximum radiation dose.

Main Results:

  • ¹⁸FLT uptake decreased in irradiated BM areas, with a more pronounced reduction in areas receiving >10% of the maximum dose.
  • ¹⁸FLT uptake was lowest immediately after CIRT, showed a partial recovery at 3 months, and remained stable for over a year.
  • No significant difference in ¹⁸FLT uptake was observed between the 10-30% and >30% dose groups.

Conclusions:

  • ¹⁸FLT uptake is a sensitive indicator of bone marrow (BM) function after radiotherapy.
  • CIRT at doses as low as <4.2-4.4 GyE per fraction can decrease BM function.
  • Doses exceeding 4.2-4.4 GyE per fraction appear to eradicate BM function in the irradiated areas.