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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Chemical Synapses01:26

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Chemical Synapses01:26

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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Published on: October 7, 2021

[Polyneuropathies--short and sweet].

Daniel Eschle1, W Jenni

  • 1RehaClinic Zurzach, Bad Zurzach. deschle@rehaclinic.ch

Praxis
|June 24, 2010
PubMed
Summary
This summary is machine-generated.

Distal-symmetric sensory polyneuropathy (PNP) causes tingling and sensory loss, often linked to diabetes. This review offers a diagnostic and management algorithm for primary care practitioners to address this common condition.

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Area of Science:

  • Neurology
  • Endocrinology
  • Primary Care Medicine

Context:

  • Distal-symmetric sensory polyneuropathy (PNP) is frequently encountered in primary care, characterized by sensory loss and tingling, particularly at night.
  • Diminished ankle reflexes and vibration perception are key clinical signs of PNP.
  • Diabetes mellitus is the leading cause of PNP in many populations, with symptoms potentially preceding diagnosis in type 2 diabetes.

Purpose:

  • To present a practical algorithm for the diagnosis of distal-symmetric sensory polyneuropathy (PNP) in a general practice setting.
  • To outline effective management strategies for PNP, focusing on primary care interventions.
  • To enhance clinician awareness of PNP, especially its association with diabetes mellitus.

Summary:

  • The mini-review details the clinical presentation of PNP, emphasizing sensory disturbances and reduced reflex/vibration sensitivity.
  • It highlights diabetes mellitus as the primary etiology, noting its long-term impact on glycemic control and nerve health.
  • An actionable diagnostic and management pathway for PNP is provided for primary care physicians.

Impact:

  • Facilitates earlier and more accurate diagnosis of PNP in primary care settings.
  • Improves patient outcomes through timely and appropriate management of polyneuropathy.
  • Increases understanding of the link between glycemic control and the development of diabetic polyneuropathy.