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Updated: Jun 12, 2026
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Ferrocene-substituted dithio-o-carborane isomers: influence on the native conformation of myoglobin protein
Chunhui Wu1, Baohua Xu, Juan Zhao
1State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, Nanjing, Jiangsu 210096, China.
Abstract:
Biointeractions between two organometallic compounds, a pair of ferrocene-substituted dithio-o-carborane isomers (C(14)H(20)B(10)FeS(2); denoted as FcSB1 and FcSB2), and myoglobin (Mb) have been investigated by means of electrochemistry, fluorescence, circular dichroism, and UV/Vis absorption spectroscopy. Our observations demonstrate that FcSB1 and FcSB2 could coordinate to the axial position trans to the histidine imidazole that induces the change of the heme iron from the high spin state to the low spin state and the changes of the conformation of the aromatic fluorophores of the selected heme protein. Such influences attribute to the structural features of FcSB1 and FcSB2 containing sulfur donor atoms and hydrophobic ferrocenyl and carboranyl units that leads to specific binding modalities with Mb. This study provides an insight into the understanding of relevant biointeractions between the new type of ferrocene-carborane conjugates and hemoproteins, and might shed light on the promising bioapplications of these multifunctional organometallic complexes.
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