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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Quetiapine for primary insomnia: a double blind, randomized controlled trial
Kanida Tassniyom1, Suchat Paholpak, Sompon Tassniyom
1Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. kanida@hotmail.com
Summary
Quetiapine 25 mg showed a trend in improving sleep time and reducing sleep latency for primary insomnia patients, with minimal side effects. Further research with larger sample sizes is recommended for definitive efficacy conclusions.
Area of Science:
- Pharmacology
- Clinical Psychology
- Sleep Medicine
Background:
- Primary insomnia is a prevalent sleep disorder affecting millions globally.
- Current treatments for insomnia have limitations and potential side effects.
- Quetiapine, an atypical antipsychotic, has not been extensively studied for primary insomnia.
Purpose of the Study:
- To investigate the clinical efficacy of a low dose of Quetiapine (25 mg) in treating primary insomnia.
- To assess the impact of Quetiapine on sleep parameters and daytime functioning.
- To evaluate the safety and tolerability of Quetiapine in this patient population.
Main Methods:
- A randomized, double-blind, placebo-controlled trial was conducted.
- Participants with primary insomnia received either Quetiapine 25 mg or placebo nightly for two weeks.
- Sleep diaries were used to measure total sleep time (TST) and sleep latency (SL), alongside assessments of daytime alertness and satisfaction.
Main Results:
- Quetiapine treatment led to a greater increase in mean TST (124.92 minutes) compared to placebo (72.24 minutes).
- Mean SL was significantly reduced with Quetiapine (96.16 minutes) versus placebo (23.72 minutes).
- Reported side effects in the Quetiapine group included dry mouth and morning drowsiness, with no statistical significance reached between groups.
Conclusions:
- Quetiapine 25 mg demonstrated a trend towards improving TST and reducing SL in primary insomnia.
- The observed improvements were associated with few side effects, suggesting a favorable safety profile.
- Larger-scale randomized controlled trials are necessary to confirm the efficacy of Quetiapine for primary insomnia.
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