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Related Concept Videos

The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Membrane Asymmetry Regulating Transporters01:19

Membrane Asymmetry Regulating Transporters

Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Energy to Drive Translocation01:37

Energy to Drive Translocation

Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...

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Related Experiment Video

Updated: Jun 12, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Time-dependent transport through molecular junctions.

San-Huang Ke1, Rui Liu, Weitao Yang

  • 1Department of Physics, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China. shke@tongji.edu.cn

The Journal of Chemical Physics
|June 25, 2010
PubMed
Summary
This summary is machine-generated.

This study explores molecular junction transport under pulsed and AC bias, revealing responses depend on junction properties and frequency. Key findings detail how electron flow behavior changes with bias type and junction conductivity.

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Last Updated: Jun 12, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
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Published on: May 11, 2013

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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)
12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)

Published on: May 27, 2012

Area of Science:

  • Condensed matter physics
  • Materials science
  • Quantum chemistry

Background:

  • Understanding electron transport in molecular junctions is crucial for nanoscale electronics.
  • Ab initio calculations and Green's function methods are key tools for theoretical investigations.

Purpose of the Study:

  • To investigate the dynamic transport properties of molecular junctions under pulsed and AC bias.
  • To elucidate the influence of molecular structure, bias conditions, and junction properties on electron flow.

Main Methods:

  • Combining time-domain Green's function solutions with ab initio density functional theory (DFT) calculations.
  • Analyzing the response of molecular junctions to short time pulses and AC biases.

Main Results:

  • Short-time response is sensitive to lead structure, bias voltage, and energy barriers.
  • Low-frequency AC bias shows resistive or capacitive behavior based on junction conductivity.
  • High-frequency AC bias leads to current lagging the bias due to kinetic inductance.

Conclusions:

  • The transition frequency from capacitive to inductive behavior is an intrinsic property of molecular junctions.
  • Dynamic bias conditions reveal complex transport phenomena not apparent in static measurements.
  • Theoretical modeling provides critical insights into the fundamental physics of charge transport at the molecular level.