Related Experiment Video
Updated: Jun 12, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Ectopic primary type A thymoma located in two thoracic vertebras: a case report
Ferdinando Marandino1, Carmine Zoccali, Nicola Salducca
1Department of Surgical Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy. marandino@ifo.it
BMC Cancer
|June 25, 2010
Summary
This study describes a rare case of thymoma, a tumor originating from the thymus, found in the D10 and D11 vertebral bodies. This finding suggests a potential thymic origin for certain spindle cell tumors in this location.
Area of Science:
- Oncology
- Pathology
- Developmental Biology
Background:
- The thymus originates from pharyngeal pouches and descends into the anterior mediastinum.
- Developmental errors can lead to aberrant thymic nodules, often associated with atypical thymomas.
Observation:
- A unique case of type-A thymoma was identified within the D10 and D11 vertebral bodies.
- Histological examination revealed uniform spindle-shaped cells with scattered lymphocytes.
- Immunohistochemistry excluded neuroectodermal, neuroendocrine, vascular, and muscular origins, confirming T-lymphocyte presence.
Findings:
- The vertebral thymoma exhibited characteristics of type-A thymoma.
- Immunohistochemical markers confirmed a thymic origin, specifically T-lymphocytes.
Implications:
- This case suggests a possible thymic histogenesis for vertebral spindle cell tumors.
- Highlights the potential for thymomas to occur in extrathoracic locations, such as vertebral bodies.
Related Concept Videos
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:25Hiatal Hernia
A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or heavy...
01:15Thoracic Aorta
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:30Pleural Disorders: Types and Brief Description
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are: