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Updated: Jun 12, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

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Published on: June 16, 2014

Association between endothelial dysfunction and hyperuricaemia.

Wan-Jing Ho1, Wen-Pin Tsai, Kuang-Hui Yu

  • 1Department of Cardiology, First Cardiovascular Division, Chang Gung Memorial Hospital, Tao-Yuan,Taiwan. auditory@adm.cgmh.org.tw

Rheumatology (Oxford, England)
|June 25, 2010
PubMed
Summary
This summary is machine-generated.

High uric acid levels (hyperuricemia) are linked to impaired blood vessel function (endothelial dysfunction). This suggests reduced nitric oxide availability may be a key factor in hyperuricemia-related vascular issues.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Area of Science:

  • Vascular Biology
  • Metabolic Disorders
  • Diagnostic Imaging

Background:

  • Hyperuricemia, characterized by elevated serum uric acid, is increasingly recognized as a potential risk factor for cardiovascular disease.
  • Endothelial dysfunction, a precursor to atherosclerosis, plays a critical role in cardiovascular health.
  • Assessing endothelial function in hyperuricemic individuals is crucial for understanding associated vascular risks.

Purpose of the Study:

  • To investigate endothelial function in patients with hyperuricemia using high-resolution peripheral vascular ultrasound.
  • To compare flow-mediated vasodilation (FMD) and nitroglycerin-mediated vasodilation between hyperuricemic patients and healthy controls.
  • To identify determinants of endothelial dysfunction in hyperuricemic individuals.

Main Methods:

  • Utilized high-resolution two-dimensional ultrasonographic imaging of the brachial artery to measure endothelium-dependent FMD and endothelium-independent vasodilation.
  • Enrolled 46 hyperuricemic patients and 46 matched healthy controls.
  • Measured serum levels of uric acid, glucose, creatinine, alanine aminotransferase (ALT), lipid profiles, and high-sensitivity C-reactive protein (CRP).

Main Results:

  • Hyperuricemic patients exhibited significantly lower FMD values compared to controls (4.45% vs. 7.10%, P < 0.001).
  • Serum uric acid levels were negatively correlated with FMD (r = -0.273, P = 0.009).
  • Multivariate analysis identified hyperuricemia (β = -0.384, P < 0.001) and body weight (β = 0.215, P = 0.017) as independent predictors of reduced FMD.

Conclusions:

  • Hyperuricemia is significantly associated with endothelial dysfunction.
  • The findings suggest that decreased nitric oxide bioavailability is a primary mechanism underlying endothelial dysfunction in hyperuricemia.
  • These results highlight the importance of managing uric acid levels to preserve vascular health.