Effect of lisdexamfetamine dimesylate on sleep in children with ADHD
John M Giblin1, Aaron L Strobel
1Clinical Study Centers LLC, Little Rock, AR, USA. giblinmd@clinstudy.com
Insights
Lisdexamfetamine dimesylate (LDX) did not significantly affect sleep in children with ADHD. Further research is needed to confirm these findings in larger ADHD populations.
Area of Science:
- Pediatric Sleep Medicine
- Neurodevelopmental Disorders
- Pharmacology
Background:
- Attention-Deficit/Hyperactivity Disorder (ADHD) is common in children.
- Sleep disturbances are frequently reported in children with ADHD.
- Lisdexamfetamine dimesylate (LDX) is a stimulant medication used to treat ADHD.
Purpose of the Study:
- To evaluate the short-term effects of LDX on objective and subjective sleep in children with ADHD.
- To assess sleep parameters using polysomnography (PSG) and actigraphy.
Main Methods:
- A randomized, double-blind, placebo-controlled study.
- 24 children aged 6-12 years with ADHD received either LDX or placebo.
- Sleep was assessed using PSG, actigraphy, and subjective measures before and after treatment.
Main Results:
- No statistically significant difference in latency to persistent sleep (LPS) between LDX and placebo groups.
- Secondary objective sleep measures generally supported the primary findings.
- Subjective sleep measures suggested potential influence from sleep hygiene counseling.
Conclusions:
- Short-term LDX treatment did not appear to cause sleep disturbances in this pediatric ADHD sample.
- Findings should be interpreted cautiously due to the small sample size and multifactorial results.
- Further studies with larger samples are required to confirm LDX's influence on sleep in children with ADHD.
Objective:
This study evaluated the potential effects of short-term treatment with lisdexamfetamine dimesylate (LDX) on both subjective and objective sleep characteristics in children aged 6 to 12 years (n = 24) with ADHD.
Method:
Polysomnography (PSG) and actigraph measures as well as assessments of subjective sleep parameters were examined in children before and after treatment with either LDX or placebo in a randomized, double-blind, single-center, parallel-group study.
Results:
There was no statistically significant increase in the primary endpoint of latency to persistent sleep (LPS) for the LDX-treated group compared to the placebo group. Secondary PSG or actigraph results generally supported primary endpoint results. Subjective sleep measure results indicated the possibility that responses are influenced by sleep hygiene counseling before and throughout the study.
Conclusions:
In this pilot sleep study in children with ADHD, LDX did not appear to contribute to any sleep disturbances as measured by both objective and subjective sleep parameters. The sample used in this study was small, and the multifarious nature of findings in this study warranted that the study conclusions be interpreted cautiously and that further study is required focusing on the influence of LDX on sleep in larger samples of ADHD children.
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