Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

Treatment Strategies for Psychological Disorders

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Differentiation of Palmoplantar Psoriasis, Palmoplantar Pustulosis and Hyperkeratotic Palmoplantar Eczema Using Proteomic Analysis of Tape Strip Samples.

Experimental dermatology·2026

Same author

Cutaneous inflammatory biomarkers in rosacea and their association with disease severity.

Clinical and experimental dermatology·2026

Same author

Prevalence of Steatotic Liver Disease with Fibrosis and Diagnostic Screening Tools in Patients with Psoriasis.

Acta dermato-venereologica·2026

Same author

Risk of major adverse cardiovascular events in patients with chronic hand eczema from the Danish National Patient Register.

The British journal of dermatology·2026

Same author

Long-term effects of repeated botulinum toxin injections in primary axillary hyperhidrosis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Same author

Anakinra alters epidermal tissue-resident memory T-cell profiles but fails to reduce clinical responses upon nickel rechallenge in individuals with nickel allergy.

The Journal of investigative dermatology·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Systemic combination treatment for psoriasis: a review.

Peter Jensen¹, Lone Skov, Claus Zachariae

¹Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Denmark. peterj01@geh.regionh.dk

Acta Dermato-Venereologica

|June 25, 2010

Summary

Systemic combination therapy can help manage psoriasis, a chronic inflammatory skin disease. However, evidence-based guidelines for these psoriasis treatments are lacking, necessitating further research into safe and effective regimens.

Related Experiment Videos

Last Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology and immunology, focusing on chronic inflammatory skin conditions.

Background:

Psoriasis affects approximately 2.6% of the population in Northern Europe and Scandinavia.
Effective disease control often requires systemic treatments, sometimes in combination.
Current evidence-based guidelines for systemic combination therapy in psoriasis are absent.

Purpose of the Study:

To review the existing literature on systemic anti-psoriatic combination regimens.
To identify knowledge gaps in the use of combined systemic treatments for psoriasis.

Main Methods:

A comprehensive literature search was conducted using PubMed.
98 papers, encompassing 116 studies (including 23 randomized controlled trials), were identified.
Studies reporting on the effects of various systemic combination treatments were analyzed.

Main Results:

The combination of retinoid and phototherapy was the most frequently investigated regimen.
The review identified various systemic combination treatments used for psoriasis management.
Data on the safety and efficacy of many combination regimens remain limited.

Conclusions:

Systemic combination therapy is utilized for psoriasis management, but lacks evidence-based guidelines.
Further controlled research is essential to establish the safest and most effective combination regimens.
Defining optimal combination strategies is crucial for improving psoriasis treatment outcomes.