Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Recycling Endosomes and Transcytosis

Recycling Endosomes and Transcytosis

The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

Receptor-Mediated Endocytosis

Receptor-Mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

Endocytosis

Endocytosis

Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either sorted through...

Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From anatomy to immunity in the gastrointestinal system.

Anatomical record (Hoboken, N.J. : 2007)·2023

Same author

Localization of host endocytic and actin-associated proteins during Shigella flexneri intracellular motility and intercellular spreading.

Anatomical record (Hoboken, N.J. : 2007)·2022

Same author

Ube2N is present and functions within listeria Actin-rich structures and lamellipodia: A localization and pharmacological inhibition study.

Anatomical record (Hoboken, N.J. : 2007)·2022

Same author

Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells.

Cellular microbiology·2018

Same author

SM22 is required for the maintenance of actin-rich structures generated during bacterial infections.

Experimental cell research·2018

Same author

IglC and PdpA are important for promoting Francisella invasion and intracellular growth in epithelial cells.

PloS one·2014

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

Hijacking the endocytic machinery by microbial pathogens.

Ann En-Ju Lin¹, Julian Andrew Guttman

¹Department of Biological Sciences, Shrum Science Centre, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

|June 25, 2010

Summary

This summary is machine-generated.

Pathogens invade host cells by hijacking endocytosis, a cellular process. Microbes like viruses and bacteria manipulate this mechanism to cause disease and offer insights into cell biology.

More Related Videos

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Published on: October 25, 2017

Related Experiment Videos

Last Updated: Jun 12, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Published on: October 25, 2017

Area of Science:

Microbiology
Cell Biology
Pathogenesis

Background:

Host cell invasion by microbes is a significant threat.
Pathogens utilize diverse strategies to enter non-phagocytic cells.
Endocytosis is a common mechanism exploited by various pathogens.

Purpose of the Study:

To review recent advances in understanding microbial manipulation of host cell endocytosis.
To explore how toxins, viruses, bacteria, and fungi cause disease by hijacking endocytosis.
To highlight the utility of studying microbial endocytic hijacking for broader cell biology insights.

Main Methods:

Literature review of recent advances in microbial pathogenesis and cell entry mechanisms.
Analysis of how different microbial agents (toxins, viruses, bacteria, fungi) manipulate endocytosis.
Discussion of the implications for understanding eukaryotic endocytic pathways.

Main Results:

Microbes frequently subvert normal endocytosis, altering particle size limits and molecular requirements for entry.
Pathogens demonstrate sophisticated hijacking of the host cell's endocytic machinery.
This microbial manipulation leads to various disease states.

Conclusions:

Understanding microbial endocytic hijacking is key to combating infectious diseases.
Microbes provide valuable models for dissecting fundamental eukaryotic endocytic processes.
Further research into these mechanisms can yield novel therapeutic strategies.