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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Design of phase-vanishing reactions
Nathan J Van Zee1, Veljko Dragojlovic
1Wilkes Honors College, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458, USA.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 25, 2010
Summary
Phase-vanishing reactions use a liquid membrane to separate reactants, offering a valuable alternative to slow reagent addition methods. This technique enables diverse reaction conditions, including anhydrous and solvent-free setups.
Area of Science:
- Organic Chemistry
- Reaction Engineering
Background:
- Phase-vanishing reactions, a novel technique introduced within the last decade, employ a perfluorinated solvent as a liquid membrane.
- This innovative approach facilitates the separation of substrates and reagents, overcoming limitations of traditional reaction setups.
Purpose of the Study:
- To highlight the advantages and versatility of phase-vanishing reactions.
- To present phase-vanishing reactions as an efficient alternative to methods requiring slow reagent addition.
Main Methods:
- Utilizing a perfluorinated solvent as a liquid membrane to compartmentalize reactants.
- Implementing various experimental designs to accommodate diverse reaction conditions.
Main Results:
- Phase-vanishing reactions provide a valuable alternative to reactions necessitating slow reagent addition.
- The method supports a wide range of reaction conditions, including anhydrous, photolytic, solvent-free, gaseous reagent, and reflux scenarios.
Conclusions:
- Phase-vanishing reactions offer a flexible and efficient synthetic strategy.
- The technique broadens the scope of accessible reaction conditions in organic synthesis.
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