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Cytotoxicity of orthodontic separating elastics
Matheus Melo Pithon1, Rogério Lacerda dos Santos, Fernanda Otaviano Martins
1Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.
Australian Orthodontic Journal
|June 26, 2010
Summary
This study found that both latex and non-latex orthodontic elastics are biocompatible, showing no significant cytotoxicity to fibroblast cells over time. This confirms their safety for use with interdental gingival tissues.
Area of Science:
- Biomaterials Science
- Dental Materials
- Cell Biology
Background:
- Separating elastics, used in orthodontics, can potentially be cytotoxic to gingival tissues.
- Both latex and non-latex elastics are common, necessitating evaluation of their biocompatibility.
Purpose of the Study:
- To assess the cytotoxicity of latex and non-latex orthodontic separating elastics.
- To determine if these materials pose a risk to interdental gingival tissues.
Main Methods:
- Cytotoxicity testing of latex and non-latex elastics using L-929 mouse fibroblasts.
- Elastics were incubated in Eagle's essential medium (MEM) for up to 168 hours.
- Cell viability was measured using the neutral red dye-uptake method and analyzed with ANOVA.
Main Results:
- Latex elastics (Groups A, D, O) showed increased cell lysis at 72 hours compared to other time points.
- Statistically significant differences in cytotoxicity were observed between latex elastics and the cell control (Group CC) at multiple time points (p > 0.05).
- No significant difference in cytotoxicity was found between one latex group (Group D) and the cell control at 24 hours.
Conclusions:
- The tested latex and non-latex orthodontic separating elastics demonstrated biocompatibility.
- The materials are considered safe for application in orthodontic treatments involving gingival tissues.
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