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Antioxidant defense in patients with chronic viral hepatitis B and C type

Emine Siber Namiduru1, Mustafa Namiduru, Mehmet Tarakçioğlu

  • 1University of Gaziantep, Faculty of Medicine, Department of Biochemistry, Gaziantep, Turkey. enamiduru@gmail.com

Clinical Laboratory
|June 26, 2010
PubMed

Insights

Patients with chronic viral hepatitis show reduced antioxidant levels, indicating an insufficient antioxidant barrier. However, these antioxidant decreases do not correlate with viral load or liver disease severity.

Area of Science:

  • Hepatology
  • Biochemistry
  • Immunology

Background:

  • Chronic viral hepatitis is associated with oxidative stress.
  • Antioxidant defense mechanisms may be compromised in patients with chronic viral hepatitis.

Purpose of the Study:

  • To evaluate erythrocyte glutathione, superoxide dismutase, catalase, glutathione peroxidase, and serum total antioxidant response in untreated chronic viral hepatitis patients.
  • To investigate the relationship between these antioxidant markers and viral load, liver fibrosis, and necro-inflammation.

Main Methods:

  • Spectrophotometric analysis of antioxidant parameters in 200 chronic viral hepatitis patients and 107 healthy controls.
  • Polymerase chain reaction for viral load determination.
  • Liver histopathology scoring (Ishak-Knodell) for necro-inflammatory activity and fibrosis.

Main Results:

  • Significantly lower levels of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, glutathione, and serum total antioxidant response were observed in patients compared to controls (p < 0.001).
  • No significant correlation was found between these antioxidant markers and viral load, necro-inflammation, or liver fibrosis.

Conclusions:

  • Patients with chronic viral hepatitis exhibit an insufficient antioxidant barrier.
  • The observed reduction in antioxidant systems is independent of viral load, necro-inflammatory activity, and liver fibrosis score.
Abstract

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