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Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
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Nonspecific biochemical changes under different health statuses and a quantitative model based on biological markers
Wang Hongwei1, Zhao Xinyu, Luan Guihong
1Department of Computer Science, Dalian Medical University, Dalian 116044, China.
Background:
To investigate the markers of systemic function by using laboratory parameters as life parameters.
Methods:
Lymphocyte count, albumin, and creatinine levels were measured using automatic analyzers in young, healthy individuals (20-39 years) and senior individuals (80-95 years) as well as in terminally ill patients. We developed a mathematic model and scoring system (indexes of systemic function, ISF) based on the above mentioned biological markers.
Results:
ISF scores were significantly lower in the senior group (P < 0.05) than those in the young, healthy group. A significant decrease was observed in the ISF of the terminally ill group and that of the senior group (P < 0.05).
Conclusions:
Our results suggest that the ISF scoring system of systemic function can be used to objectively evaluate the systemic function in individuals with different health statuses.
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