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Related Experiment Video

Updated: Jun 12, 2026

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication

Published on: July 18, 2025

Novel carboxyl-amine bonding methods for poly(dimethylsiloxane)-based devices.

Eric Ouellet¹, Cheng Wei T Yang, Tao Lin

¹Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.

Langmuir : the ACS Journal of Surfaces and Colloids

|June 26, 2010

Summary

This study introduces a new room-temperature bonding method for poly(dimethylsiloxane) (PDMS) devices using chemical surface modifications. This technique creates strong peptide bonds, offering a versatile alternative for device fabrication.

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Last Updated: Jun 12, 2026

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Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Published on: January 17, 2017

Area of Science:

Materials Science
Surface Chemistry
Biotechnology

Background:

Poly(dimethylsiloxane) (PDMS) is widely used in microfluidics and biomedical devices.
Reliable and versatile bonding techniques are crucial for fabricating complex PDMS-based devices.
Current bonding methods often require harsh conditions or specific surface treatments.

Purpose of the Study:

To develop a novel, room-temperature, irreversible bonding technique for PDMS devices.
To functionalize PDMS and inorganic substrates for covalent bond formation.
To expand the available surface chemistries for PDMS device assembly.

Main Methods:

PDMS surfaces were functionalized with primary amine groups.
Glass and gold substrates were functionalized with carboxylic acid groups.
Amine-terminated PDMS and carboxyl-terminated substrates were brought into contact at room temperature to form peptide bonds.

Main Results:

Irreversible bonding was achieved via peptide bond formation at room temperature.
Shear tests demonstrated bond strengths comparable to conventional methods.
Surface characterization using water contact angle and X-ray photoelectron spectroscopy (XPS) confirmed successful conjugation.

Conclusions:

A novel, room-temperature chemical bonding technique for PDMS devices has been successfully demonstrated.
The method utilizes amine-functionalized PDMS and carboxyl-functionalized substrates (glass/gold).
This technique offers a versatile and robust approach for PDMS device fabrication, expanding surface chemistry options.