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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 12, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Drug repurposing for drug development in stroke.

Susan C Fagan1

  • 1College of Pharmacy, University of Georgia, Augusta, Georgia 30912, USA. sfagan@mail.mcg.edu

Pharmacotherapy
|June 26, 2010
PubMed
Summary

Drug repurposing offers a safer alternative for acute stroke treatment development. Exploring existing medications for secondary vascular protective effects may improve neuronal recovery and patient outcomes.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Developing novel acute stroke treatments has faced significant challenges with high failure rates.
  • Drug repurposing, utilizing existing safe medications for new therapeutic applications, presents a lower-risk strategy.
  • Focusing on drugs with secondary activities, particularly vascular protection, is a key area of investigation.

Purpose of the Study:

  • To explore the potential of drug repurposing for acute ischemic stroke treatment.
  • To identify agents with multiple mechanisms of action, emphasizing vascular protection.
  • To highlight the benefits of protecting the ischemic vasculature for neuronal recovery.

Main Methods:

  • Investigating marketed drugs for their secondary pharmacological activities.

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Last Updated: Jun 12, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

  • Analyzing existing clinical trial data for evidence of vascular protection in stroke patients.
  • Reviewing potential therapeutic agents including statins, angiotensin II receptor blockers, minocycline, and growth factors.

    • Main Results:

    • Drug repurposing is a viable strategy to overcome the failures in developing new stroke treatments.
    • Vascular protection is crucial for promoting neuronal recovery and long-term benefits in stroke patients.
    • Angiotensin II receptor blockers, like candesartan, have shown demonstrated vascular protection in acute ischemic stroke clinical trials.

    Conclusions:

    • Drug repurposing offers a promising avenue for developing effective and safe acute stroke therapies.
    • Targeting vascular protection is essential for improving outcomes in stroke patients.
    • Existing drugs, such as candesartan, can be effectively repurposed to treat acute ischemic stroke.