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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
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CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Related Experiment Video

Updated: Jun 12, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

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Published on: August 22, 2025

Biomedical benefits of cannabinoids?

C H Ashton1

  • 1Department of Psychiatry, University of Newcastle upon Tyne, UK.

Addiction Biology
|June 26, 2010
PubMed
Summary

Cannabinoids show therapeutic promise, particularly for nausea relief, though evidence for other uses like pain or epilepsy is limited. Further research is needed to evaluate their role in medicine.

Area of Science:

  • Pharmacology
  • Clinical Medicine

Background:

  • Cannabinoids are investigated for potential therapeutic effects including antiemetic, antispasmodic, analgesic, and appetite-stimulating properties.
  • Current scientific evidence supporting these uses, except for antiemetic effects, is sparse, with many claims relying on anecdotal reports.

Purpose of the Study:

  • To review clinical trials involving cannabinoids such as delta-9-tetrahydrocannabinol (THC), nabilone, and levonantradol.
  • To discuss the advantages and adverse effects of cannabinoids in clinical practice.
  • To evaluate the potential place of cannabinoids in modern medicine.

Main Methods:

  • Review of existing clinical trials on cannabinoids.
  • Analysis of data concerning therapeutic effects, advantages, and adverse effects.

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  • Discussion of the current evidence base for various medical indications.

    • Main Results:

    • Cannabinoids demonstrate established efficacy as antiemetics.
    • Evidence for other therapeutic indications (e.g., epilepsy, glaucoma, asthma, analgesia, antispasmodics) is largely anecdotal and requires further scientific validation.
    • The mechanisms of action for most therapeutic effects remain largely unknown.

    Conclusions:

    • Cannabinoids may hold value as adjuncts for symptom management in conditions where standard treatments are insufficient.
    • Further rigorous clinical evaluation is necessary to establish the definitive role and efficacy of cannabinoids in medicine.
    • While promising, particularly for symptom control, the clinical utility of cannabinoids requires more robust scientific evidence.