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Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Published on: August 6, 2013
The dopamine D2 receptor (DRD2) gene-a genetic risk factor in heavy smoking?
A Batra1, G Gelfort, M Bartels
1Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany. albatra@med.uni-tuebingen.de
Abstract:
Indications of a genetic predisposition to nicotine dependence have been derived from numerous epidemiological data and from individual genetic studies suggesting the involvement of the dopaminergic D2 receptor. Previous association studies defined the TaqlA polymorphism as a risk factor for addiction, in particular for alcoholism and tobacco dependence. Results of investigations into this polymorphism in 110 severely addicted smokers and a control group of 60 population-matched German non-smokers did not support these findings. However, our results indicate an association between the DRD2-Fokl-1 allele and the onset and intensity of smoking.
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