Related Experiment Video
Updated: Jun 12, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Reversible bone pain and symmetric bone scan uptake in a dialysis patient treated with cinacalcet: a case report
Oliver Lenz1, Rhea Sancassani, Carla Bottino
1Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida, USA. afornoni@med.miami.edu.
Introduction:
The medical management of secondary hyperparathyroidism in patients with end-stage renal disease involves a combination of dietary restrictions, phosphate binders, active vitamin D analogs, and calcimimetics.
Case Presentation:
We report the case of a 36-year-old Hispanic dialysis patient, originally from Cuba and now residing in the USA, who developed severe bone pain and muscle twitching after starting low dose cinacalcet, despite normal pre-dialysis ionized calcium and elevated parathyroid hormone. The clinical symptoms correlated with increased symmetrical uptake on bone scan that resolved rapidly upon discontinuation of cinacalcet.
Conclusion:
Cinacalcet may induce severe bone pain and a unique bone scan uptake pattern in hemodialysis patients.
Related Concept Videos
Chronic Kidney Disease II: Clinical Manifestations
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Skeleton and Calcium Homeostasis
Urinary Tract Calculi III: Medical Management
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
