Graphical simulation environments for modelling and simulation of integrative physiology
Related Experiment Video
Updated: Jun 12, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Violeta Mangourova1, John Ringwood, Bruce Van Vliet
1Dept. of Electronic Engineering, NUI Maynooth, Ireland. violeta.i.mangourova@nuim.ie
Abstract:
Guyton's original integrative physiology model was a milestone in integrative physiology, combining significant physiological knowledge with an engineering perspective to develop a computational diagrammatic model. It is still used in research and teaching, with a small number of variants on the model also in circulation. However, though new research has added significantly to the knowledge represented by Guyton's model, and significant advances have been made in computing and simulation software, an accepted common platform to integrate this new knowledge has not emerged. This paper discusses the issues in the selection of a suitable platform, together with a number of current possibilities, and suggests a graphical computing environment for modelling and simulation. By way of example, a validated version of Guyton's 1992 model, implemented in the ubiquitous Simulink environment, is presented which provides a hierarchical representation amenable to extension and suitable for teaching and research uses. It is designed to appeal to the biomedical engineer and physiologist alike.
More Related Videos
10:50Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
10:44Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
Related Concept Videos
Model Approaches for Pharmacokinetic Data: Physiological Models
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Growth Models with Integration: Problem Solving
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Pharmacokinetic Models: Overview
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
Modeling and Similitude