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FADD: a regulator of life and death

Léa Tourneur1, Gilles Chiocchia

  • 1Inserm, U1016, Institut Cochin, Département d'Immunologie-Hématologie, Paris, France. lea.remy-tourneur@parisdescartes.fr

Trends in Immunology
|June 26, 2010
PubMed

Insights

FAS-associated protein with death domain (FADD) is vital for cell death and other processes like proliferation and immunity. Its diverse functions, often independent of death receptors, are regulated by its location and phosphorylation state.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Immunology

Background:

  • FAS-associated protein with death domain (FADD) acts as a key adaptor protein in transmitting apoptotic signals via death receptors (DRs).
  • FADD's known roles extend beyond apoptosis to include proliferation, cell cycle, tumor development, inflammation, innate immunity, and autophagy.

Purpose of the Study:

  • To explore the multifaceted roles of FADD beyond its canonical function in apoptosis.
  • To investigate the mechanisms regulating FADD's diverse cellular functions, particularly those independent of DRs.

Main Methods:

  • Review of existing literature on FADD's functions and regulatory mechanisms.
  • Analysis of studies investigating FADD's involvement in various cellular processes.
  • Examination of research on FADD localization and phosphorylation as regulatory factors.

Main Results:

  • FADD mediates critical cellular processes including apoptosis, proliferation, and immune responses.
  • Many newly identified FADD functions are independent of DR signaling pathways.
  • Protein localization and phosphorylation state critically dictate FADD's specific cellular functions.

Conclusions:

  • FADD is a versatile and essential regulator of numerous cellular processes.
  • Understanding FADD's regulatory networks offers insights into other multifunctional proteins.
  • FADD's context-dependent functions highlight its significance in maintaining cellular homeostasis and disease pathogenesis.

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