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Women in Steady Exercise Research (WISER): study design and methods.
Andrea Y Arikawa1, Maureen O'Dougherty, Beth C Kaufman
1Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA. aarikawa@umn.edu
Contemporary Clinical Trials
|June 26, 2010
Summary
This study investigated how exercise training impacts breast cancer risk factors in young women. Findings will help understand exercise’s role in reducing cancer risk.
Area of Science:
- Reproductive Health
- Oncology
- Exercise Physiology
Background:
- Observational studies suggest a link between physical activity and reduced breast cancer risk.
- The Women's Intervention and Exercise for Reproductive Health (WISER) trial investigates exercise's effects on breast cancer risk factors.
Purpose of the Study:
- To examine the impact of a structured exercise intervention on oxidative stress, hormone levels, and metabolic factors related to breast cancer risk.
- To explore the physiological mechanisms through which exercise may influence breast cancer etiology.
Main Methods:
- Recruitment of sedentary women aged 18-30 without hormonal contraceptive use.
- Randomization into an exercise intervention (5x45 min/week at 65-70% max HR) or control group for 4 menstrual cycles.
- Collection of blood, urine, and dietary data to assess biomarkers like F2-isoprostanes, hormones, and estrogen metabolites.
Main Results:
- 319 women completed the study out of 391 enrolled; overall dropout rate was 18.4%.
- No significant demographic differences between completers and dropouts, except for education level.
- Data analysis is ongoing to determine the effects of exercise on measured biomarkers.
Conclusions:
- The WISER trial provides valuable data on exercise's physiological effects relevant to breast cancer risk.
- Understanding these mechanisms can inform strategies for breast cancer prevention through physical activity.
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