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[Decrease of the functional affinity of rheumatoid factors under the effect of tiopronin].

R Albouy1, B Bendaoud, R Casburn-Budd

  • 1Centre Hospitalier Régional et Universitaire, Brest.

Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|April 1, 1991
PubMed
Summary

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Tiopronin treatment significantly reduced rheumatoid factor (RF) and its functional affinity in rheumatoid arthritis patients. This suggests tiopronin may restore sialyl transferase activity in B lymphocytes.

Area of Science:

  • Rheumatology
  • Immunology
  • Biochemistry

Context:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and the presence of rheumatoid factor (RF).
  • RF is a key biomarker in RA, and its levels and function are associated with disease activity and severity.
  • Synovial fluid (SF) provides a localized environment for immune responses in RA.

Purpose:

  • To investigate the effects of tiopronin (TP) on rheumatoid factor (RF) titers, levels, and functional affinity in patients with rheumatoid arthritis (RA).
  • To examine the impact of TP treatment on the proportion of asialylated IgG in serum and synovial fluid (SF) of RA patients.
  • To explore the potential mechanism by which TP influences immune cell function, specifically sialyl transferase activity.

Summary:

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  • A 2-month treatment with tiopronin (TP) in 16 rheumatoid arthritis (RA) patients led to significant reductions in both agglutinating and non-agglutinating rheumatoid factor (RF) titers and levels in serum and synovial fluid (SF).
  • The functional affinity of the remaining RF was significantly attenuated in both serum and SF following TP treatment.
  • Conversely, the proportion of asialylated IgG was notably enhanced in both serum and SF after TP administration.

Impact:

  • These findings suggest that tiopronin (TP) may modulate RF characteristics and IgG glycosylation in rheumatoid arthritis (RA).
  • The observed changes indicate a potential restoration of sialyl transferase efficacy at the B lymphocyte level by TP.
  • This study provides insights into the immunomodulatory mechanisms of tiopronin (TP) in rheumatoid arthritis (RA) treatment.