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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Sergio E Alvarez1, Kuzhuvelil B Harikumar, Nitai C Hait

  • 1Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA.

Nature
|June 26, 2010
PubMed
Summary

Sphingosine-1-phosphate (S1P) acts as a cofactor for TRAF2, a key enzyme in TNF-alpha signaling. This discovery reveals a new mechanism for regulating NF-kappaB activation, crucial for inflammation and immunity.

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