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Updated: Jun 12, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and (19)F MRI oximetry
Steven H Ubert Baete1, Jan Vandecasteele, Luc Colman
1Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Gent, Belgium. steven.baete@ugent.be
Objective:
This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of (19)F MRI oximetry.
Materials And Methods:
The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. (19)F relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner.
Results:
Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom.
Conclusions:
The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with (19)F MRI oximetry.
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