Related Experiment Video
Updated: Jun 12, 2026
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
MR elastography of the ex vivo bovine globe
Daniel V Litwiller1, Sung J Lee, Arunark Kolipaka
1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Purpose:
To evaluate the feasibility of using MR elastography (MRE) to assess the mechanical properties of the eye.
Materials And Methods:
The elastic properties of the corneoscleral shell of an intact, enucleated bovine globe specimen were estimated using MRE and finite element modeling (FEM), assuming linear, isotropic behavior. The two-dimensional (2D), axisymetric model geometry was derived from a segmented 2D MR image, and estimations of the Young's modulus in both the cornea and sclera were made at various intraocular pressures using an iterative flexural wave speed matching algorithm.
Results:
Estimated values of the Young's moduli of the cornea and sclera varied from 40 to 185 kPa and 1 to 7 MPa, respectively, over an intraocular pressure range of 0.85 to 9.05 mmHg (1.2 to 12.3 cmH(2)O). They also varied exponentially as functions of both wave speed and intraocular dP/dV, an empirical measure of "ocular rigidity."
Conclusion:
These results show that it is possible to estimate the intrinsic elastic properties of the corneoscleral shell in an ex vivo bovine globe, suggesting that MRE may provide a useful means to assess the mechanical properties of the eye and its anatomy. Further development of the technique and modeling process will enhance its potential, and further investigations are needed to determine its clinical potential.
