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Updated: Jun 12, 2026
08:44
Mouse Heterotopic Cervical Cardiac Transplantation Utilizing Vascular Cuffs
Published on: June 23, 2022
Ischemic cardiac complications following G-CSF
Peter M Eckman1, Stefan C Bertog, Robert F Wilson
1Department of Medicine, Division of Cardiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA. eckmanp@umn.edu
Summary
Granulocyte-colony stimulating factor (G-CSF) can mobilize progenitor cells but may pose cardiac risks. This study highlights potential ischemic complications in patients with coronary artery disease receiving G-CSF.
Area of Science:
- Hematology
- Cardiology
- Oncology
Background:
- Granulocyte-colony stimulating factor (G-CSF) is a key therapeutic agent for mobilizing hematopoietic stem and progenitor cells, primarily in bone marrow transplantation.
- Its potential benefits in treating myocardial infarction have been explored, but cardiovascular safety remains a significant concern, particularly in patients with pre-existing coronary artery disease.
Observation:
- Two cases are presented where patients experienced ischemic cardiac complications shortly after G-CSF administration.
- These events suggest a potential link between G-CSF treatment and adverse cardiovascular outcomes in susceptible individuals.
Findings:
- The administration of G-CSF was temporally associated with the onset of ischemic cardiac events in the described cases.
- A review of existing literature indicates that G-CSF may carry significant cardiovascular risks, especially in patients with coronary artery disease.
Implications:
- Clinicians should exercise caution when considering G-CSF treatment for patients with coronary artery disease due to the potential for serious cardiac complications.
- Further research is warranted to fully elucidate the cardiovascular risks associated with G-CSF and to identify patient populations who may be at higher risk.
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