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Hemoptysis in children with pandemic influenza H1N1 2009 infection
Lucksamee Haura1, Boonyarat Warachit, Jarika Makkoch
1Department of Pediatrics, Hatyai Hospital, Songkhla, Thailand.
Insights
Previously healthy children with influenza A H1N1 experienced hemoptysis and pneumonia. Prompt oseltamivir treatment led to rapid recovery, avoiding intubation, highlighting effective antiviral therapy for pediatric H1N1 cases.
Area of Science:
- Pediatric Infectious Diseases
- Respiratory Virology
- Clinical Medicine
Background:
- Influenza A H1N1 outbreaks can affect school-aged children.
- Hemoptysis is a rare but serious complication of pediatric influenza.
- Early diagnosis and treatment are crucial for managing severe influenza cases.
Observation:
- Three previously healthy children presented with hemoptysis following influenza outbreaks.
- Symptoms included fever, rhinorrhea, severe cough, and hemoptysis, with two cases showing viral pneumonia.
- One child experienced massive hemoptysis, but coagulation profiles were normal.
Findings:
- All patients tested positive for human pandemic influenza A H1N1 via RT-PCR.
- Nasopharyngeal swabs confirmed H1N1 infection; sputum tests for tuberculosis were negative.
- Rapid and complete recovery was observed in all patients following oseltamivir treatment.
Implications:
- Oseltamivir is an effective treatment for severe pediatric influenza A H1N1, including cases with hemoptysis.
- This case series underscores the importance of considering influenza in children presenting with hemoptysis.
- Timely antiviral intervention can prevent severe outcomes like respiratory failure and the need for mechanical ventilation.
Abstract:
Three patients were admitted to Hat Yai Hospital, Songkhla Thailand with hemoptysis. They were previously healthy children aged 6, 13, and 14 years old who had attended schools in which outbreaks of influenza had occurred. They all had a history of fever, rhinorrhea, and severe cough accompanied by hemoptysis. Two developed hemoptysis on Day 3 and the third on Day 6 of illness, with one of them displaying massive hemoptysis. Chest radiographs were compatible with viral pneumonia in two cases and the third case was unremarkable. Coagulation profiles in the severe case were carried out and were normal. All the patients responded very well to treatment with oseltamivir and did not require intubation. Their subsequent nasopharyngeal swabs were positive for human pandemic influenza A H1N1 by real-time reverse transcription-polymerase chain reaction (RT-PCR), and their sputum for acid-fast bacilli and tuberculin skin tests were negative.
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