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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 12, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

Is Src a viable target for treating solid tumours?

B Elsberger¹, B Stewart, O Tatarov

¹Glasgow Western Infirmary, Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Level 2, McGregor Building, Dumbarton Road, Glasgow G11 0NT, Scotland, UK.

Current Cancer Drug Targets

|June 29, 2010

Summary

This summary is machine-generated.

The proto-oncogene Src regulates cell growth and transformation. Elevated Src activity is linked to various cancers, making Src inhibitors a promising therapeutic target for solid tumors.

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Last Updated: Jun 12, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Published on: February 17, 2019

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Published on: May 8, 2018

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Oncology
Molecular Biology
Cellular Biology

Background:

Src is the first identified proto-oncogene, crucial for cell signaling and transformation.
Src dysfunction, via overexpression or hyperactivation, significantly impacts cellular functions.
Elevated Src is observed in numerous solid tumors, implicating it in carcinogenesis.

Purpose of the Study:

To review in vitro and in vivo data on Src's role in oncogenesis and metastasis.
To examine Src's association with key cancer hallmarks.
To summarize the therapeutic potential of Src inhibitors for solid tumors.

Main Methods:

Review of in vitro and in vivo studies on Src function.
Analysis of data from human tumor tissues and translational research.
Compilation of information on current Src inhibitor development and trials.

Main Results:

Src dysregulation contributes to increased cell proliferation, survival, motility, and invasiveness.
Src is associated with decreased cell adhesion, enhanced angiogenesis, and bone activity.
Evidence from human tumors and translational studies supports Src's role in oncogenesis.

Conclusions:

Src is a significant molecular target for solid tumor therapy.
Src inhibitors are under development and clinical trials.
Further clinical data are required to confirm the utility of Src inhibitors in solid tumor treatment.