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Updated: Jun 12, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

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Published on: March 7, 2018

Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore

Alessa Jaendling1, Ramsay J McFarlane

  • 1North West Cancer Research Fund Institute, College of Natural Sciences, Bangor University, Memorial Building, Deiniol Road, Bangor, Gwynedd, LL57 2UW, United Kingdom.

The Biochemical Journal
|June 29, 2010
PubMed

Insights

Translin and its partner TRAX are crucial proteins involved in diverse cellular functions, including RNA metabolism and genome stability. Their roles in processes like RNA interference are key to understanding eukaryotic cell biology.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Translin and its binding partner TRAX are conserved proteins with diverse biological roles.
  • Their precise functions in processes like cell growth and genome stability are not fully understood.
  • Both proteins exhibit nucleic acid-binding activity, suggesting a central role in nucleic acid metabolism.

Purpose of the Study:

  • To review the biological and biochemical properties of Translin and TRAX.
  • To elucidate the central role of Translin and TRAX in eukaryotic cell biology.
  • To highlight their involvement in RNA interference pathways.

Main Methods:

  • Literature review of existing studies on Translin and TRAX.
  • Analysis of biochemical and biological data.
  • Synthesis of information regarding protein functions and interactions.

Main Results:

  • Translin and TRAX are implicated in cell growth, mRNA processing, spermatogenesis, neuronal function, and genome stability.
  • Nucleic acid binding is a key characteristic, indicating a role in nucleic acid metabolism and distribution.
  • Translin and TRAX function as enhancer components in RNA interference (RNAi) pathways.

Conclusions:

  • Translin and TRAX play a central and important role in eukaryotic cell biology.
  • Understanding their nucleic acid-binding and RNAi pathway involvement is critical.
  • Further research is needed to fully clarify their functions in various biological processes.

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