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Updated: Jun 12, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Macroprolactinoma revealed by an exophthalmos]
F Harzallah1, L Harzallah, A Ben Brahim
1Service d'endocrinologie-diabétologie, Hôpital La Rabta, Tunis, Tunisie. fatma.harzallah@rns.tn
Journal Francais D'Ophtalmologie
|June 29, 2010
Summary
This case study highlights a rare giant prolactinoma in a woman, initially presenting with unusual vision loss and exophthalmos. Prompt bromocriptine treatment effectively lowered prolactin levels, demonstrating successful management of this pituitary tumor.
Area of Science:
- Endocrinology
- Neuro-ophthalmology
- Oncology
Background:
- Giant prolactinomas are rare pituitary tumors that can cause significant mass effects.
- Diagnosis can be delayed, especially when presenting with atypical symptoms.
Observation:
- A 54-year-old woman presented with unilateral exophthalmos, oculomotor paralysis, and vision loss.
- Headaches and secondary amenorrhea were also reported, with imaging revealing a large sellar mass.
Findings:
- Hormonal investigation confirmed a giant prolactinoma (prolactin level 8723 ng/ml) and revealed hypopituitarism.
- Bromocriptine treatment led to a rapid decrease in prolactin levels to <200 ng/ml within one month.
Implications:
- This case underscores the importance of considering pituitary tumors in patients with unexplained visual disturbances.
- Early diagnosis and treatment of giant prolactinomas are crucial for preserving vision and pituitary function.
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