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Updated: Jun 12, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
[Conjunctival Kaposi sarcoma]
J Sudzinski1, F Thomas, A Berthout
1Service d'ophtalmologie, centre Saint-Victor, CHU d'Amiens, 354, boulevard de Beauville, 80054 Amiens, France. juliensudzinskioph@hotmail.fr
Abstract:
Kaposi sarcoma is rare and occurs in four forms (classic, endemic, post-transplant and epidemic), which all have the same histological appearance associated with the same viral agent: human herpes virus type 8 (HHV-8). Conjunctival and palpebral locations are, however, rare, and only 30 cases have been described in the literature. We present the case of a 34-year-old woman with conjunctival Kaposi angiosarcoma, with rare bulbar location associated with superior palpebral telangiectases against a rare immunodepression syndrome (common variable immunodeficiency). The treatment consisted of an excision biopsy with an over-and-over suture of a conjunctival rotation flap, combined with anti-HHV-8 chemotherapy to effect a regression of the palpebral lesion. However, the reappearance of a conjunctival lesion on the rim of the excision site required local radiotherapy of approximately 30 Gy, with no recurrence after 1 month.
Insights
This study details a rare case of conjunctival Kaposi sarcoma in a woman with common variable immunodeficiency. Treatment involved surgery, chemotherapy, and radiotherapy, successfully managing the human herpes virus type 8 (HHV-8) related angiosarcoma.
Area of Science:
- Oncology
- Ophthalmology
- Virology
Background:
- Kaposi sarcoma is a rare cancer associated with human herpes virus type 8 (HHV-8).
- Conjunctival and palpebral Kaposi sarcoma are exceptionally rare ocular manifestations.
- Common variable immunodeficiency is a rare condition predisposing to various infections and malignancies.
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