Related Experiment Video
Updated: Jun 12, 2026
09:29
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Do the obsessive-compulsive symptoms have an effect in schizophrenia?
Ahmet Tiryaki1, Evrim Ozkorumak
1Faculty of Medicine Department of Psychiatry, Karadeniz Technical University, Trabzon 61080, Turkey.
Comprehensive Psychiatry
|June 29, 2010
Summary
Schizophrenia patients with obsessive-compulsive (OC) symptoms show more severe psychotic symptoms and lower quality of life. However, their neurocognitive functions remain comparable to those without OC symptoms.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Schizophrenia exhibits diverse symptom domains and functional outcomes.
- Obsessive-compulsive (OC) symptoms in schizophrenia require further clarification.
- Understanding the interplay between OC symptoms and schizophrenia is crucial for targeted interventions.
Purpose of the Study:
- To compare schizophrenia patients with and without OC symptoms.
- To analyze differences in symptom domains, cognitive functions, and quality of life.
- To elucidate the clinical profile of schizophrenia with comorbid OC symptoms.
Main Methods:
- Sixty-two schizophrenia patients were assessed over 12 months.
- Diagnostic and symptom severity were evaluated using standardized clinical interviews and scales.
- Neuropsychological tests and quality of life assessments were administered.
Main Results:
- 35.5% of schizophrenia patients presented with OC symptoms.
- Patients with OC symptoms exhibited more severe psychotic symptoms and poorer quality of life.
- No significant differences in neurocognitive functions were observed between groups.
Conclusions:
- Schizophrenia patients with OC symptoms present a distinct clinical picture.
- These patients experience more severe psychosis and impaired functioning.
- Despite poor functioning, neurocognition appears preserved in this subgroup.
Related Concept Videos
01:28Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
01:29Psychological and Sociocultural Causes of Schizophrenia
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
01:24Personality Disorders: Dependent and Obsessive-Compulsive
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...
01:17Schizophrenia
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.