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Updated: Jun 12, 2026

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Mathematically defined tissue engineering scaffold architectures prepared by stereolithography.

Ferry P W Melchels1, Katia Bertoldi, Ruggero Gabbrielli

  • 1MIRA Institute for Biomedical Technology and Technical Medicine, Department of Polymer Chemistry and Biomaterials, University of Twente, Enschede, The Netherlands.

Biomaterials
|June 29, 2010
PubMed
Summary

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Stereolithography enables versatile tissue engineering scaffold fabrication using various materials and precise design control. This technology allows tuning mechanical properties for diverse applications, from rigid to elastic scaffolds.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Additive Manufacturing

Background:

  • Conventional tissue engineering scaffold fabrication methods limit material selection and design flexibility.
  • Developing advanced scaffolds with tailored properties is crucial for regenerative medicine.

Purpose of the Study:

  • To demonstrate the versatility of stereolithography for creating tissue engineering scaffolds with high design freedom and diverse material options.
  • To characterize the accuracy, mechanical properties, and design-based tunability of stereolithography-fabricated scaffolds.

Main Methods:

  • Designing porous scaffolds using computer software.
  • Fabricating scaffolds from poly(D,L-lactide)-based and poly(D,L-lactide-co-epsilon-caprolactone)-based resins using stereolithography.

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Last Updated: Jun 12, 2026

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  • Characterizing scaffold architecture via micro-computed tomography.
  • Evaluating mechanical properties in compression and comparing with finite element predictions.

    • Main Results:

    • Stereolithography accurately reproduced designed scaffold architectures, confirmed by micro-computed tomography.
    • Mechanical properties in compression showed good agreement with finite element analysis predictions.
    • Scaffold mechanical properties were tunable by adjusting material composition and pore architecture.

    Conclusions:

    • Stereolithography offers significant freedom in designing tissue engineering scaffolds with a wide range of mechanical properties.
    • The presented technology and materials enable precise fabrication of scaffolds, from rigid and strong to highly flexible and elastic.
    • This approach advances the development of customized scaffolds for various tissue engineering applications.