Related Experiment Video
Updated: Jun 11, 2026

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts
Published on: March 2, 2017
Luteal phase progesterone increases live birth rate after frozen embryo transfer
Kerstin Bjuresten1, Britt-Marie Landgren, Outi Hovatta
1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Objective:
To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles.
Design:
Prospective randomized controlled trial.
Setting:
University-based hospital.
Subject(S):
Four hundred thirty-five women undergoing embryo transfer in natural cycles.
Intervention(S):
The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support.
Main Outcome Measure(S):
Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate.
Result(S):
Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate.
Conclusion(S):
Progesterone supplementation improves live birth rate after embryo transfer in natural cycles.
More Related Videos
Related Concept Videos
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Ovarian Cycle
Proliferative Phase
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

