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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 11, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Intraosseous ameloblastoma.

Candice C Black1, Rocco R Addante, Carrie A Mohila

  • 1Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. candice.c.black@hitchcocok.org

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|June 29, 2010
PubMed
Summary
This summary is machine-generated.

Ameloblastomas are aggressive, slow-growing tumors that can cause significant bone destruction. Treatment depends on the subtype, with complete excision recommended for most, but unicystic types require further classification.

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Surgical Treatment of an Endolymphatic Sac Tumor
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Last Updated: Jun 11, 2026

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Published on: May 26, 2023

Area of Science:

  • Oral pathology
  • Surgical oncology
  • Dental medicine

Background:

  • Ameloblastomas are benign, locally aggressive neoplasms originating from odontogenic epithelium.
  • These tumors exhibit slow growth, extensive bone erosion, and rare metastatic potential.
  • Histologically, they mimic embryonic ameloblasts and stellate reticulum, with three main subtypes identified.

Purpose of the Study:

  • To summarize the characteristics, subtypes, and treatment considerations for ameloblastomas.
  • To highlight the diagnostic features and management strategies for ameloblastoma variants.

Main Methods:

  • Review of existing literature on ameloblastoma pathology and treatment.
  • Classification of ameloblastomas into conventional, unicystic, and desmoplastic subtypes.
  • Analysis of factors influencing treatment planning, including tumor size, location, and patient health.

Main Results:

  • Ameloblastomas present as large tumors with substantial bone destruction.
  • Three distinct subtypes exist: conventional, unicystic, and desmoplastic.
  • Treatment decisions are guided by tumor characteristics and patient factors.

Conclusions:

  • Complete surgical excision is the standard treatment for conventional and desmoplastic ameloblastomas.
  • The unicystic variant necessitates further subtyping to guide optimal therapeutic strategies.
  • Understanding ameloblastoma subtypes is crucial for effective clinical management and prognosis.