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Lessons from models of pancreatic beta cells for engineering glucose-sensing cells

Arthur Sherman1

  • 1National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Biological Modeling, Bethesda, MD 20892-5621, USA. asherman@nih.gov

Mathematical Biosciences
|June 29, 2010
PubMed
Abstract

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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