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[Insulin level--a parameter for risk of arteriosclerosis?]
1Lehrkrankenhaus München-Schwabing.
Versicherungsmedizin
|April 1, 1991
Summary
High insulin levels, whether naturally occurring or from treatment, may increase the risk of cardiovascular disease. Research links excess insulin to coronary heart disease and vascular complications.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolic Research
Context:
- Emerging evidence suggests a potential link between insulin and cardiovascular complications.
- Both endogenous hyperinsulinemia and exogenous insulin therapy with high doses are implicated.
- Population studies in non-diabetics and type II diabetics highlight this association.
Purpose:
- To investigate the role of insulin in promoting cardiovascular complications.
- To examine the association between insulin concentration and coronary heart disease risk.
- To explore the in-vitro mechanisms by which insulin affects vascular walls.
Summary:
- Excessive insulin concentrations at vascular walls may promote cardiovascular complications.
- Studies indicate serum insulin concentration is an independent risk predictor for coronary heart disease.
- In-vitro data show insulin stimulates smooth muscle cell proliferation and lipid synthesis in the vascular wall.
- Large population studies link hyperinsulinemia and high exogenous insulin requirements to macroangiopathy and coronary heart disease risk in type II diabetics.
Impact:
- This research highlights a potential adverse effect of insulin therapy and hyperinsulinemia.
- Findings may influence clinical guidelines for insulin use and management of metabolic disorders.
- Further investigation is warranted to understand the precise mechanisms and clinical implications.