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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: Jun 11, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Specific targets in sarcoma and developmental therapeutics.

David M Thomas1, Andrew J Wagner

  • 1Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. david.thomas@petermac.org

Journal of the National Comprehensive Cancer Network : JNCCN
|June 29, 2010
PubMed
Summary

Recent advancements in targeted and nontargeted therapies for connective tissue tumors highlight key drug development themes. Understanding specific pathway dependencies, like the insulin-like growth factor 1 pathway in Ewing

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

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Published on: October 14, 2016

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Connective tissue tumors present diverse subtypes with significant therapeutic implications.
  • Many subtypes exhibit distinct phenotypes and genotypes crucial for treatment strategies.

Purpose of the Study:

  • To review recent therapeutic agent applications in connective tissue tumors.
  • To illustrate key themes in drug development, including targeted and nontargeted approaches.
  • To explore the role of specific pathways, such as insulin-like growth factor 1, in cancer.

Main Methods:

  • Review of recent literature on targeted and nontargeted therapeutic agents.
  • Analysis of drug development paradigms, including oncogene and lineage addiction.
  • Examination of specific pathway roles in connective tissue tumors like Ewing's sarcoma.

Main Results:

  • Targeted therapies have successfully leveraged oncogene and lineage addiction principles.
  • The insulin-like growth factor 1 pathway presents a complex target in Ewing's sarcoma.
  • Variability in pathway criticality across cancers and individuals is observed.

Conclusions:

  • Understanding pathway dependencies is crucial for advancing personalized medicine.
  • Identifying why certain pathways are critical in specific contexts remains an important research area.
  • Novel therapeutic opportunities can emerge from a deeper comprehension of these mechanisms.