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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO
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Published on: July 7, 2014

Imaging genomics.

Paul M Thompson1, Nicholas G Martin, Margaret J Wright

  • 1Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-7332, USA. thompson@loni.ucla.edu

Current Opinion in Neurology
|June 29, 2010
PubMed
Summary
This summary is machine-generated.

Imaging genomics links brain structure and function to genes, aiding disease risk identification. Collaborative efforts and advanced imaging analysis reveal gene effects for public health applications.

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Published on: May 9, 2011

Area of Science:

  • Neuroscience
  • Genetics
  • Medical Imaging

Background:

  • Imaging genomics integrates brain imaging with genetic data.
  • Advanced techniques like HARIDI and resting-state fMRI provide detailed brain connectivity measures.
  • Genetic analysis of brain imaging data is crucial for understanding brain function and disease.

Purpose of the Study:

  • To review the emerging field of imaging genomics.
  • To highlight the identification of genes influencing brain structure, function, and disease risk.
  • To discuss the application of advanced neuroimaging and genetic analysis methods.

Main Methods:

  • Utilizing high-throughput genotyping (genome-wide scans).
  • Employing advanced neuroimaging techniques like high angular resolution diffusion imaging and resting-state functional MRI.
  • Applying voxel-wise genomic methods for detailed genetic association mapping across the brain.

Main Results:

  • Discovery of candidate genes with small to moderate effects on brain measures.
  • Voxel-wise genomic methods enable precise mapping of gene effects throughout the brain.
  • Successful replication of gene effects through collaborative, worldwide imaging genomics efforts.

Conclusions:

  • Imaging genomics facilitates the discovery and replication of gene-brain associations.
  • Studying brain phenotypes closer to gene action enhances the detectability of gene effects.
  • This field has significant implications for understanding and managing dementia, mental illness, and public health.