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Updated: Jun 11, 2026
05:31
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
Acute aortic dissection: microenvironmental regulation
1Cardiothoracic Division, Department of Surgery, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA. tbilfinger@notes.cc.sunysb.edu
Summary
Acute aortic dissections and other vascular events show non-random patterns, suggesting biological rhythms influence their occurrence. Further research into regulatory pathways is needed to understand these critical cardiovascular events.
Area of Science:
- Cardiovascular Research
- Vascular Biology
- Chronobiology
Background:
- Acute aortic dissections are often perceived as random events, except for rare genetic connective tissue disorders.
- The majority of aortic dissections follow patterns similar to other catastrophic vascular events.
- Emerging evidence challenges the notion of randomness in these cardiovascular catastrophes.
Purpose of the Study:
- To review evidence for circadian, seasonal, and weekly rhythms in acute aortic dissections and other vascular events.
- To explore the association between vascular events and emotional stress.
- To highlight the need for modern molecular examinations of regulatory pathways.
Main Methods:
- Review of existing evidence on temporal patterns in vascular events.
- Analysis of data from registries like the International Registry of Aortic Dissection (IRAD).
- Consideration of vascular neuroimmunological observations.
Main Results:
- Evidence suggests acute aortic dissections and other vascular events exhibit non-random temporal patterns.
- Circadian, seasonal, and weekly rhythms are implicated in the timing of these events.
- Emotional stress is also associated with an increased risk of vascular events.
Conclusions:
- Acute aortic dissections and vascular events are not random, but influenced by biological rhythms.
- Understanding the steering of circadian variation is crucial, though poorly understood.
- Speculations on microenvironmental regulatory pathways are proposed based on vascular neuroimmunology.
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