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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Convergence of Sequences01:26

Convergence of Sequences

A sequence is a function defined on the natural numbers that assigns a value to each index. It can be understood as an ordered list of terms generated one after another. In mathematical analysis, an important question is whether the terms of a sequence approach a single real number as the index becomes very large. When this happens, the sequence is said to converge, and the value approached is called the limit. From a graphical perspective, convergence means that the plotted terms approach a...
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Conservation of Protein Domains02:26

Conservation of Protein Domains

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

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Related Experiment Video

Updated: Jun 11, 2026

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Limits of sequence and functional conservation.

Len A Pennacchio, Axel Visel

    Nature Genetics
    |June 29, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Sequence conservation across species often implies functional conservation. However, this study reveals significant differences in human and mouse stem cell regulatory networks, cautioning against direct extrapolation from sequence to function.

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    Published on: July 14, 2015

    Related Experiment Videos

    Last Updated: Jun 11, 2026

    Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
    16:02

    Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

    Published on: February 10, 2023

    An Integrated Approach for Microprotein Identification and Sequence Analysis
    09:37

    An Integrated Approach for Microprotein Identification and Sequence Analysis

    Published on: July 12, 2022

    Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
    07:08

    Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

    Published on: July 14, 2015

    Area of Science:

    • Comparative genomics
    • Stem cell biology
    • Regulatory network analysis

    Background:

    • Noncoding DNA sequence conservation is frequently used as a proxy for functional conservation across species.
    • Understanding regulatory networks is crucial for stem cell biology and developmental processes.

    Discussion:

    • This study highlights significant divergence in stem cell regulatory networks between humans and mice, despite potential sequence similarities in noncoding DNA.
    • The findings challenge the assumption that sequence conservation directly translates to conserved gene regulatory functions in stem cells.

    Key Insights:

    • Human and mouse stem cell regulatory networks exhibit substantial differences.
    • Generalizing functional conservation from noncoding DNA sequence conservation requires careful consideration.

    Outlook:

    • Future research should focus on experimental validation of functional conservation rather than relying solely on sequence conservation.
    • This work has implications for cross-species translational research in stem cell therapy and developmental biology.