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Related Experiment Video

Updated: Jun 11, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Formulation design of fast disintegrating tablets using disintegrant blends.

S B Shirsand¹, Sarasija Suresh, P V Swamy

¹Department of Pharmaceutical Technology, H. K. E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105, India.

Indian Journal of Pharmaceutical Sciences

|June 29, 2010

Summary

Fast disintegrating tablets of prochlorperazine maleate were developed using superdisintegrants crospovidone and croscarmellose sodium. The best formulation showed significantly faster drug release compared to conventional tablets.

Keywords:

Cros-carmellose sodium Prochlorperazine maleate crospovidone fast disintegrating tablets

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Published on: August 9, 2022

Area of Science:

Pharmaceutical Technology
Drug Delivery Systems

Background:

Patient compliance is a challenge with conventional oral dosage forms.
Fast disintegrating tablets (FDTs) offer an alternative for improved patient adherence.

Purpose of the Study:

To design and evaluate fast disintegrating tablets of prochlorperazine maleate using a direct compression method.
To investigate the synergistic effect of superdisintegrants crospovidone and croscarmellose sodium on tablet disintegration and drug release.

Main Methods:

Prochlorperazine maleate FDTs were prepared by direct compression using varying concentrations of crospovidone and croscarmellose sodium.
Formulations were evaluated for physical characteristics, drug content uniformity, in vitro dispersion time, wetting time, and water absorption ratio.
The optimal formulation was assessed for in vitro drug release in phosphate buffer (pH 6.8) and short-term stability.

Main Results:

A combination of 3% crospovidone and 5% croscarmellose sodium (DCPC(4)) resulted in optimal fast disintegration (approx. 12 s).
The DCPC(4) formulation exhibited significantly enhanced in vitro drug release (t(50%) = 7.0 min) compared to a commercial conventional tablet (t(50%) = 17.4 min).
Short-term stability studies showed no significant changes in drug content or dispersion time.

Conclusions:

The direct compression method is effective for producing prochlorperazine maleate FDTs.
The combination of crospovidone and croscarmellose sodium acts synergistically to improve disintegration and drug release.
The developed FDT formulation demonstrates potential for improved therapeutic efficacy and patient compliance.